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SABCS Abstract: A predictive test for neoadjuvant chemotherapy in breast cancer identifies a subset of triple negative patients with resistant disease and the poorest prognosis

2018-04-20T23:26:18+00:00

A predictive test for neoadjuvant chemotherapy in breast cancer identifies a subset of triple negative patients with resistant disease and the poorest prognosis Prediction of pathological complete response (pCR) for neoadjuvant treatment is an area of unmet clinical need, especially for triple negative breast cancer (TNBC) as pCR is correlated [...]

SABCS Abstract: A predictive test for neoadjuvant chemotherapy in breast cancer identifies a subset of triple negative patients with resistant disease and the poorest prognosis 2018-04-20T23:26:18+00:00

Startup’s diagnostics test aims to reshape breast cancer treatment

2018-04-26T20:50:19+00:00

Startup's diagnostics test aims to reshape breast cancer treatment As founder and CEO of BioArray Therapeutics Inc., a Connecticut-based cancer diagnostics startup, Marcia Fournier has heard from hundreds of breast cancer patients and their families about the physical, emotional and financial toll that chemotherapy treatments have taken on them. "After [...]

Startup’s diagnostics test aims to reshape breast cancer treatment 2018-04-26T20:50:19+00:00

SABCS Abstract: Gene expression profiles accompanying phenotypic changes during non-malignant breast epithelial cells acini formation to explain MRI phenotypes

2018-04-20T05:38:00+00:00

Gene expression profiles accompanying phenotypic changes during non-malignant breast epithelial cells acini formation to explain MRI phenotypes Magnetic resonance imaging (MRI) captures the three dimensional way in which tumors are organized in the breast, defined as imaging phenotypes in the I-SPY 1 trial. We developed a gene set based on [...]

SABCS Abstract: Gene expression profiles accompanying phenotypic changes during non-malignant breast epithelial cells acini formation to explain MRI phenotypes 2018-04-20T05:38:00+00:00

Experiments that Point to a New Understanding of Cancer

2018-04-26T20:51:25+00:00

Mina Bissel: Experiment that point to a new a new understanding of cancer For decades, researcher Mina Bissell pursued a revolutionary idea -- that a cancer cell doesn't automatically become a tumor, but rather, depends on surrounding cells (its microenvironment) for cues on how to [...]

Experiments that Point to a New Understanding of Cancer 2018-04-26T20:51:25+00:00

ASCO Abstract: Use of gene expression signature to predict response to combination chemotherapy in breast cancer clinical subgroups.

2018-04-20T05:51:01+00:00

Use of gene expression signature to predict response to combination chemotherapy in breast cancer clinical subgroups. Accurate stratification of patients prior to treatment with combination chemotherapy would allow non-responders to receive an alternative treatment in a timely manner and potentially improve clinical outcomes. We describe a 22-gene signature that accurately [...]

ASCO Abstract: Use of gene expression signature to predict response to combination chemotherapy in breast cancer clinical subgroups. 2018-04-20T05:51:01+00:00

AACR Abstract: 22-gene signature predicts response to chemotherapy in a broad range of breast cancer subtypes

2018-04-20T05:49:05+00:00

 22-gene signature predicts response to chemotherapy in a broad range of breast cancer subtypes Only 15-25% of breast cancer patients from all histopathological subtypes currently respond to primary chemotherapy with a complete pathological response (pCR) and there is currently no test in widespread clinical use to predict whether a patient [...]

AACR Abstract: 22-gene signature predicts response to chemotherapy in a broad range of breast cancer subtypes 2018-04-20T05:49:05+00:00

ASCO Abstract: Predictive value of a gene signature evaluated in multiple chemotherapy regimens for breast cancer.

2018-04-20T05:55:49+00:00

Predictive value of a gene signature evaluated in multiple chemotherapy regimens for breast cancer. Approximately 12,800 U.S. women present with locally advanced breast cancer each year. Primary (or neoadjuvant) chemotherapy is a treatment to shrink a large tumor to a size that allows it to be removed with breast conserving [...]

ASCO Abstract: Predictive value of a gene signature evaluated in multiple chemotherapy regimens for breast cancer. 2018-04-20T05:55:49+00:00

AACR Abstract: Gene expression signatures as predictors of chemotherapeutic response in breast cancer

2018-04-20T06:00:24+00:00

Gene expression signatures as predictors of chemotherapeutic response in breast cancer The purpose of this study is to evaluate a novel 22-gene signature as a predictor of response to chemotherapy in breast cancer. The extent of residual viable tumor following chemotherapy is the most important predictor of long-term outcome in [...]

AACR Abstract: Gene expression signatures as predictors of chemotherapeutic response in breast cancer 2018-04-20T06:00:24+00:00

Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells

2018-04-20T20:37:23+00:00

Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells PTEN is a dual function phosphatase with tumor suppressor function compromised in a wide spectrum of cancers. Because tissue polarity and architecture are crucial modulators of normal and malignant behavior, we postulated that PTEN may [...]

Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells 2018-04-20T20:37:23+00:00

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets

2018-04-20T20:43:36+00:00

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets One of the major tenets in breast cancer research is that early detection is vital for patient survival by increasing treatment options. To that end, we have previously used a novel unsupervised approach to [...]

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets 2018-04-20T20:43:36+00:00