Transcriptome Profiling in Clinical Breast Cancer: From 3D Culture Models to Prognostic Signatures

Early detection has been one of the most effective strategies to control the growing cancer burden. The power of earlier detection has been demonstrated by the impact of pap‐smear, mammography, and PSA tests on cancer patient treatment and survival. However, in many cases, we are still losing the battle against cancer because patients that initially presented with low‐grade disease progress rapidly to aggressive forms of the disease. The theme of this review article is to briefly summarize innovative strategies using three‐dimensional (3D) cell cultures of human mammary epithelial cells to predict clinical outcome in breast cancer. This strategy has the potential to further enhance our understanding of breast cancer biology and to contribute to the identification of biologically significant bio‐markers that are also useful drug targets.

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