Gene expression profiles accompanying phenotypic changes during non-malignant breast epithelial cells acini formation to explain MRI phenotypes

Magnetic resonance imaging (MRI) captures the three dimensional way in which tumors are organized in the breast, defined as imaging phenotypes in the I-SPY 1 trial. We developed a gene set based on the way in which breast epithelial cells aggregate and organize in three dimensional cultures. We investigated whether these organizational genes correspond to the imaging phenotypes. The results suggest that the MRI phenotypes may be a manifestation of the organization genes that determine behavior in three dimensional culture.

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